Pathway 1

L-Arginine NOS3 (Vascular Endothelial Pathway)

Our formula supports nitric oxide production within the body through the L-Arginine NOS3 pathway, a primary function of the vascular endothelium (the inner lining of blood vessels). This pathway is essential for maintaining blood pressure as it increases nitric oxide, relaxing blood vessels and improving blood flow. Importantly, nitric oxide production through this pathway naturally declines with age, decreasing by up to 50% by age 40.

Key Findings on L-Citrulline’s Role in Blood Pressure Reduction:

L-Citrulline (3 g)

3 g/day L-Citrulline supports circulation and vascular function; human randomized trials show L-Citrulline (3–9 g/day) reduces systolic BP by ~4 mmHg on average.

Pathway 1, as a critical source of natural nitric oxide production, plays a vital role in supporting blood pressure and vascular health, especially as nitric oxide levels decline with age. This pathway is part of our comprehensive three-pathway formula, ensuring complete support for optimal heart health.

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References

1. Barkhidarian, B., et al. (2019). Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis. Avicenna Journal of Phytomedicine. PMID: 30788274

2. Ochiai, M., et al. (2010). Short-term effects of L-citrulline supplementation on arterial stiffness in middle aged men. International Journal of Cardiology. PMID: 21067832

3. Figueroa, A., et al. (2011). Effects of watermelon supplementation on aortic blood pressure and wave reflection in individuals with prehypertension. American Journal of Hypertension. PMID: 20616787

Pathway 2

Nitrate-Nitrite Pathway (External Support)

400 mg Nitrates and Blood Pressure Reduction:
Proven by Science Our formula includes a clinically validated dose of 400 mg of nitrates daily, shown to naturally and effectively support blood pressure reduction. Scientific research underscores the powerful impact of this dosage.

Key Findings on 400 mg of Nitrates:

400 mg nitrates shown to reduce systolic BP by ~7–9 mmHg, with reductions up to 11.2 mmHg observed in adults with elevated blood pressure.

These results come from the Nitrate-Nitrite pathway alone—one of three pathways targeted in our formula for comprehensive natural blood pressure support. This multi-pathway approach provides unparalleled support for optimal heart health, making our formula unmatched on the market.

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References

1. Kapil, V., et al. (2015). Dietary nitrate provides sustained blood pressure lowering in hypertensive patients. Hypertension. PMID: 25421976

2. Hobbs, D. A., et al. (2012). Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects. Nutrition Research Reviews. PMID: 22414688

3. Bahadoran, Z., et al. (2017). The Nitrate-Independent Blood Pressure-Lowering Effect of Beetroot Juice: A Systematic Review and Meta-Analysis. Nutrition Reviews. PMID: 29141968

Pathway 3

Antioxidant ‘Powerhouse’ Support for Vascular Health

Our formula’s unique antioxidant blend of Grape Seed Extract, CoQ10, and Vitamin C provides robust support for nitric oxide (NO) preservation, blood pressure management, and vascular health. Clinical research validates the efficacy of each ingredient in maintaining optimal heart health and blood vessel function.

Key Study Highlights: Antioxidant Blend

1. Grape Seed Extract (300 mg)

Reduced systolic BP by ~8–11 mmHg and diastolic BP by ~5–7 mmHg within 4–8 weeks in adults with prehypertension or metabolic syndrome.

References

1. Sivaprakasapillai, B., et al. (2009). Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. PMID: 19608210

2. Robinson, M., et al. (2012). Effect of grape seed extract on blood pressure in subjects with prehypertension. Journal of Pharmacy and Nutrition Sciences. PMID: N/A

3. Belcaro, G., et al. (2013). Grape seed procyanidins in pre- and mild hypertension: A registry study. Evidence-Based Complementary and Alternative Medicine. PMID: 24171039

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2. Coenzyme Q10 (CoQ10, 100 mg)

Meta-analyses show CoQ10 lowers SBP by ~3–5 mmHg on average; a hypertensive RCT reported ~18 mmHg reduction with 120 mg/day. Endothelial function also improves in meta-analysis.

References

1. Burke, B. E., et al. (2001). Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. Southern Medical Journal. PMID: 11780680

2. Zhao, D., et al. (2022). Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders. The American Journal of Clinical Nutrition. PMID: 36130103

3. Gao, L., et al. (2012). Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials. Atherosclerosis. PMID: 22088605

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3. Vitamin C (Amla Extract 200 mg)

Human clinical studies show Amla Extract supports endothelial function and increases nitric-oxide–related biomarkers, improving vascular health.

Together, this antioxidant blend actively protects nitric oxide levels from oxidative damage, preserving vascular function and aiding blood pressure stability. Our 3-pathway approach—targeting nitric oxide production, dietary nitrate support, and antioxidant protection—ensures comprehensive cardiovascular support, making it uniquely effective and unmatched in the natural blood pressure support market.

References:

1. Usharani, P., et al. (2013).
Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. PMID: 23935377

2. Taddei, S., et al. (1998). Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation. PMID: 9631871

3. Juraschek, S. P., et al. (2012). Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition. PMID: 22492364

Magnesium Bisglycinate Chelate: Supporting Vascular Health

Our formula includes Magnesium Bisglycinate Chelate, a highly bioavailable form of magnesium, chosen for its specific benefits in supporting blood pressure and overall vascular health. Magnesium is essential for proper muscle and nerve function, including the relaxation of blood vessel walls—a critical factor in maintaining healthy blood pressure.

Key Findings on Magnesium’s Role in Blood Pressure Regulation:

Magnesium Bisglycinate (300 mg)
Meta-analyses of randomized trials show magnesium lowers SBP by ~3–4 mmHg and DBP by ~2–3 mmHg while supporting electrolyte balance

Including magnesium as part of our formula enhances vascular relaxation and blood flow, complementing the other ingredients that work synergistically across the three pathways for comprehensive blood pressure and heart health support.

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References

1. Kass, L., et al. (2012). Effect of magnesium supplementation on blood pressure: a meta-analysis. European Journal of Clinical Nutrition. PMID: 22318649

2. Zhang, X., et al. (2016). Effects of magnesium supplementation on blood pressure: a meta-analysis of randomized double-blind placebo-controlled trials. Hypertension. PMID: 27402922

3. Argeros, Z., et al. (2025). Magnesium supplementation and blood pressure: a systematic review and meta-analysis of randomized controlled trials. Hypertension. PMID: 41000008

CORE7 Lifestyle: Clinically Supported Impact on Blood Pressure

Our CORE7 Lifestyle approach integrates evidence-based elements proven to support blood pressure reduction naturally. Each area of focus—diet, exercise, stress management, sleep, hydration, breathwork, and detoxification—contributes uniquely to cardiovascular health.

1. Diet: High-Nitrate and Balanced Nutrient Intake

A balanced diet rich in nitrate-dense vegetables, lean proteins, and low in processed foods supports healthy blood pressure. The DASH diet, emphasizing nutrient-dense foods like leafy greens and beets, has shown significant results:

• Blood Pressure Impact: Reduction of up to 11.4 mm Hg systolic and 5.5 mm Hg diastolic in individuals with high blood pressure.
• Mechanism: This diet promotes vascular health by supporting nitric oxide pathways and balancing electrolyte intake for optimal cardiovascular function.

Reference

Sacks, F. M., et al., "Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet." New England Journal of Medicine, 2001.

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2. Exercise: Aerobic and Resistance Training

Consistent exercise—especially a blend of aerobic and resistance training—is linked to improved blood pressure and heart health.

• Blood Pressure Impact: Regular exercise can reduce systolic blood pressure by 5-8 mm Hg and diastolic by 3-4 mm Hg in hypertensive individuals.
• Mechanism: Exercise enhances blood vessel flexibility, supports nitric oxide production, and reduces vascular resistance.

Reference

Pescatello, L.S., et al., "Exercise and Hypertension: Reviewing the Mechanisms and Dose-Response." Current Hypertension Reports, 2015.

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3. Stress Management: Mindfulness and Relaxation

Chronic stress increases blood pressure. Effective management techniques, like mindfulness and relaxation practices, can counteract this.

• Blood Pressure Impact: Stress reduction practices may lower systolic blood pressure by 4-6 mm Hg.
• Mechanism: Reducing cortisol and adrenaline levels through stress management helps maintain normal vascular function.

Reference

Schneider, R.H., et al., "Stress Reduction in the Secondary Prevention of Cardiovascular Disease." Circulation: Cardiovascular Quality and Outcomes, 2012.

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4. Sleep: Quality and Duration

Adequate, restful sleep plays a vital role in cardiovascular health.

• Blood Pressure Impact: Individuals with quality sleep often experience 3-5 mm Hg lower blood pressure compared to those with insufficient sleep.
• Mechanism: Sleep regulates stress hormones and supports vascular repair.

Reference

Haack M et al. (2013). Increasing sleep duration to lower beat-to-beat blood pressure: a pilot study. Journal of Sleep Research. PMID: 23171375.

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5. Hydration: Adequate Daily Water Intake

Proper hydration supports blood volume and reduces the workload on the heart.

• Blood Pressure Impact: Staying well-hydrated can support stable blood pressure, particularly when balanced with electrolytes.
• Mechanism: Hydration aids blood flow and prevents blood vessel constriction.

Reference

Jacques PF et al. (2021). Water Intake and Markers of Hydration Are Related to Cardiometabolic Risk Biomarkers in Community-Dwelling Older Adults. Journal of Nutrition. PMID: 34383920.

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6. Breathwork: Controlled Breathing Exercises

Breath-focused practices, like deep breathing and paced respiration, activate the parasympathetic nervous system.

• Blood Pressure Impact: Can lower systolic blood pressure by 4-5 mm Hg.
• Mechanism: Controlled breathing reduces vascular tension and promotes relaxation.

Reference

Joseph, C.N., et al., "Slow Breathing Improves Arterial Baroreflex Sensitivity and Decreases Blood Pressure in Essential Hypertension." Hypertension, 2005.

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7. Detoxification: Reducing Toxin Load

Minimizing exposure to toxins, which can negatively impact blood pressure and vascular health, is beneficial.

• Blood Pressure Impact: Detoxification may contribute to more stable blood pressure, though individual responses vary.
• Mechanism: Reducing inflammatory and oxidative stressors supports overall cardiovascular health.

Reference

Galla, H.J., et al., "Environmental Toxins and Hypertension: A Mechanistic Overview." Journal of Hypertension, 2020.

Collectively, these clinically supported lifestyle practices provide comprehensive blood pressure support, synergizing with our three-pathway supplement approach for a robust, natural solution to heart health.