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Performance · 4 min read

Blood Flow, Performance and Recovery

Blood flow is the whole game: energy, the pump, and why injuries heal slowly. Oxygen in, waste out, repair materials delivered. Every part of training and recovery runs on circulation, and circulation runs on nitric oxide. Here is what the human studies show, and why an elbow takes so long to heal.

Blood Flow, Performance and Recovery

Ask anyone who trains what nitric oxide does and they will say "the pump". That is true, and it is the least interesting thing it does. The pump is a sign that the arteries feeding a working muscle have widened. The same widening is what delivers oxygen during a hard effort, clears what the effort leaves behind, and brings the materials for repair afterwards. Blood flow is not a feature of performance and recovery. It is the medium they happen in.

Energy and endurance

Dietary nitrate does something unusual: it lowers the oxygen cost of exercise. In healthy volunteers, three days of nitrate supplementation reduced the amount of oxygen needed to sustain a given workload.1 Beetroot juice did the same, and extended time to exhaustion during hard exercise.2 In a cycling time trial, it improved performance by around 2.8 percent, a large margin at that level.3 A meta-analysis across dozens of trials confirmed a small but consistent improvement in endurance performance.4


Doing the same work on less oxygen is what "more energy" feels like from the inside. It is also why the nitrate pathway matters more as you age: your own nitric oxide production falls by about half between 20 and 40,5 and the nitrate route is the one that doesn't.

The pump, properly understood

L-citrulline feeds the pathway your vessel lining uses to make its own nitric oxide, and it arrives in the blood far more efficiently than arginine does.6 The vasodilation that follows is the pump. Beyond vanity, it is more blood through the muscle during the set, which is more oxygen and more nutrient delivery while the muscle is working hardest.

    Recovery is a delivery problem. Everything a damaged tissue needs arrives by blood, and everything it needs to get rid of leaves the same way.

    Recovery

    Soreness after training is partly the by-products of effort sitting in the tissue and partly the inflammation of repair. Both resolve faster with better flow. In a randomised crossover trial, 8 grams of citrulline malate before a heavy resistance session reduced muscle soreness at 24 and 48 hours by around 40 percent and increased the number of repetitions completed.7 Antioxidants that protect nitric oxide, and the minerals that muscle contraction runs on, magnesium, potassium and zinc, are the rest of the recovery picture.

    Why the elbow takes so long

    Tendons and ligaments heal slowly, and the reason is circulation. They have a sparse blood supply compared with muscle, and parts of some tendons are almost avascular.8 Less blood, slower delivery of the cells and materials that rebuild tissue, slower clearance of what shouldn't be there. This is why a strained elbow or Achilles can take months when a muscle strain takes weeks. It is also why researchers have tested delivering nitric oxide to injured tendons directly, with improved healing in several trials.9 Blood flow is the limiting factor in repair, everywhere in the body.

    What this means for how you train 

    • Treat circulation as a training variable, not a side effect. The warm-up, the breathing, the hydration and the sleep are all blood-flow decisions.
    • Get the doses the studies used. Nitrate in the hundreds of milligrams, citrulline in grams; the label should say so.
    • Protect what you make. Smoke, excess alcohol and antiseptic mouthwash all cut nitric oxide; the first two also slow repair.
    • Measure. Blood pressure is the simplest daily readout of how your arteries are doing, and the Blueprint shows how to take it.

    References

    1. Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. Effects of dietary nitrate on oxygen cost during exercise. Acta Physiologica 2007;191(1):59–66.

    2. Bailey SJ, Winyard P, Vanhatalo A, et al. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. Journal of Applied Physiology 2009;107(4):1144–1155.

    3. Lansley KE, Winyard PG, Bailey SJ, et al. Acute dietary nitrate supplementation improves cycling time trial performance. Medicine and Science in Sports and Exercise 2011;43(6):1125–1131.

    4. McMahon NF, Leveritt MD, Pavey TG. The effect of dietary nitrate supplementation on endurance exercise performance in healthy adults: a systematic review and meta-analysis. Sports Medicine 2017;47(4):735–756.

    5. Sverdlov AL, Ngo DT, Chan WP, Chirkov YY, Horowitz JD. Aging of the nitric oxide system: are we as old as our NO? Journal of the American Heart Association 2014;3(4):e000973.

    6. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. British Journal of Clinical Pharmacology 2008;65(1):51–59.
    7. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. Journal of Strength and Conditioning Research 2010;24(5):1215–1222.
    8. Fenwick SA, Hazleman BL, Riley GP. The vasculature and its role in the damaged and healing tendon. Arthritis Research 2002;4(4):252–260.
    9. Murrell GAC. Using nitric oxide to treat tendinopathy. British Journal of Sports Medicine 2007;41(4):227–231.

    Study findings describe the cited trials at the doses shown; they are not a promise about your results. Nothing in the Journal is individual medical advice. If you take medication, keep taking it and talk to your physician.*

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