Core3Vitality

Introduction

Nitric oxide (NO) is a powerful molecule produced by endothelial cells lining blood vessels, playing a critical role in maintaining blood flow, blood pressure, and vascular health. Here, we explore NO’s benefits, how it works in the body, and why optimal levels are crucial for wellness.

Understanding Nitric Oxide and Its Core Functions

NO acts as a vital signalling molecule for cardiovascular health: 

1. Vasodilation: NO relaxes blood vessels, boosting circulation and supporting blood pressure regulation (1).
2. Blood Thinner: NO reduces platelet aggregation, lowering the risk of blood clots (2).
3. Anti-Clotting Agent: It maintains smooth vessel walls, reducing plaque buildup and clot risk (3).

 Three Main Pathways of Nitric Oxide Production 

HeartHealth-BP supports NO levels across three essential pathways, making it one of the best nitric oxide supplements on the market: 

1. L-Arginine NOS3 Pathway
   This pathway produces NO from L-arginine via nitric oxide synthase (NOS) in the vascular endothelium. HeartHealth-BP uses L-citrulline due to its higher bioavailability, bypassing the liver and converting to NO in the kidneys. NO efficiency declines with age, lowering NO by up to 50% by age 40, emphasizing the need for natural NO boosters (4).
2. Nitrate-Nitrite Pathway
   Dietary nitrates, such as those in beets, convert to NO, supporting cardiovascular health and complementing the L-arginine pathway. 400 mg of dietary nitrates daily is shown to effectively sustain NO levels (5).
3. Antioxidant Support Pathway
   Reactive oxygen species (ROS) and free radicals degrade NO, impacting its efficacy. Antioxidants like CoQ10, grape seed extract, and vitamin C protect NO from oxidative agents, extending its activity in the bloodstream (6). 

Top 10 Causes of Death in the U.S. Linked to Low Nitric Oxide Levels 

Low NO levels correlate with several chronic conditions and leading mortality factors, including: 

1. Heart disease
2. Cancer
3. Chronic respiratory diseases
4. Stroke
5. Alzheimer’s
6. Diabetes
7. Kidney disease
8. Influenza and pneumonia
9. Septicaemia
10. Liver disease

Low NO levels often lead to high blood pressure, which exacerbates vascular inflammation, heightening risks for many of these conditions (7).

Chronic Conditions Associated with Low Nitric Oxide

Persistent low NO levels are linked to various conditions:

• Hypertension: Reduced NO decreases blood vessel flexibility, raising BP (8).
• Atherosclerosis: Low NO allows plaque buildup, hardening arteries (9).
• Cognitive Decline: Low NO lowers brain blood flow, impacting cognitive health. 

Maintaining NO can mitigate risks and improve cardiovascular health. 

How to Naturally Boost Nitric Oxide Levels

1. Eat Nitrate-Rich Foods
   Foods like beets and dark leafy greens convert to NO through the Nitrate-Nitrite pathway. Aim for 400 mg of dietary nitrates daily to maintain NO levels (10).
2. Exercise Regularly
   Physical activity stimulates NO production, supporting blood pressure, circulation, and vascular health.
3. Supplement with L-Citrulline
   HeartHealth-BP includes 1250 mg of L-citrulline, effectively bypassing the liver and aiding NO production naturally. L-Citrulline is a core ingredient in the best nitric oxide supplements due to its high bioavailability.
4. Increase Antioxidant Intake
   Antioxidants, including CoQ10, grape seed extract, and vitamin C, reduce oxidative stress, preserving NO levels in the bloodstream (11).